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Xifaxan (rifaximin) is a member of the miscellaneous antibiotics drug class and is commonly used for Hepatic Encephalopathy, Irritable Bowel Syndrome, and Traveler's Diarrhea. In clinical studies, the most common side effects of XIFAXAN in IBS-D were nausea (feeling sick to your stomach) and an increase in liver enzymes. You can work with your doctor and your pharmacist to get the right dosage for your needs into the least expensive pill options. What Xifaxan is and what it is used for. Call your doctor if your symptoms do not improve after 24 to 48 hours, or if they get worse while using this medicine Xifaxan (rifaximin) is a member of the miscellaneous antibiotics drug class and is commonly used for Hepatic Encephalopathy, Irritable Bowel Syndrome, and Traveler's Diarrhea. 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